Aptamers in Virology

Sotiris Missailidis

Abstract


Aptamers are short, single stranded RNA or DNA oligonucleotides, capable of selectively recognising targets of interest. Their chemical properties and
enormous variety in the initial selection library render them capable of high affinity and specificity for a variety of ligands, ranging from small molecules to
proteins, enzymes, receptors or polysaccharides. At the same time, their relatively small size and nature permits them storage and transport at ambient temperatures, lack of immunogenicity, rapid clearance and interesting pharmacokinetic and pharmacodynamic properties, as well as flexibility in chemical modification and labelling for reporter applications. Thus,
aptamers, having recently reached their 25th birthday, have seen a boom in the number of applications and disease conditions where they have been used, either as diagnostic or therapeutic modalities, apart from their flexibility as high affinity laboratory reagents.


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DOI: http://dx.doi.org/10.17525/vrrjournal.v21i2.278

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