ANTIBODIES ANTI-ORTHOPOXVIRUS IN HEALTHY WORKERS WHO HANDLE ANIMALS AND IN PATIENTS WITH CUTANEOUS LESIONS COMPATIBLE WITH POXVIRUS INFECTION IN THE STATE OF RIO DE JANEIRO, BRAZIL

Ortrud Monika Barth, Hermann G. Schatzmayr, Márcia Cristina Rosa Gonçalves, Débora Ferreira Barreto-Vieira, Jorlan Fernandes, Monique Queiroz Lima, Renata Carvalho de Oliveira, Elba Regina Sampaio de Lemos

Abstract


The incidence of poxvirosis, a zoonosis caused by viruses of the family Poxviridae, has increased over the past two decades in Brazil. The important features of the Orthopoxvirus infection include rapid spread, occurrence restricted to lactating cows, lack of hygiene, person-to-person spread, and occurrence at properties where milking is conducted. We detected the presence of vaccinia virus antibodies, specifically for Cantagalo virus, in samples from two distinct populations from the state of Rio de Janeiro: (i) healthy professionals who live in the State of Rio de Janeiro and handle animals and (ii) in patients with cutaneous lesions compatible with poxvirosis. The plaque reduction neutralisation test (PRNT) was used. Of the 136 samples from the group of healthy professionals, 12 displayed seroreactivity with titres lower than or equal to 1/10. Anti-poxvirus antibodies were detected in 68.3% of samples of patients suspected to be infected with poxvirus (28/41). Therefore, the plaque reduction neutralisation test constitutes a sensitive assay that can be more commonly used for diagnosis. Furthermore, professionals who handle animals should be included as an occupational risk group in areas with confirmed human poxvirus cases.

DOI: http://dx.doi.org/10.17525/vrr.v19i1.105


Full Text:

PDF


DOI: http://dx.doi.org/10.17525/vrr.v19i1.105

Refbacks

  • There are currently no refbacks.


Copyright (c)

Creative Commons License All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License